Mechanisms of Fusion-Driven Oncogenesis in Childhood Cancers (U01 Clinical Trial Not Allowed)

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to solicit applications for basic research projects investigating the molecular mechanisms by which fusion oncoproteins drive pediatric cancers. The overall goal of this solicitation and the companion NOFO, RFA-CA-23-037, is to form a new dynamic network of investigators that will use rigorous and collaborative efforts to advance our understanding of the mechanisms of action of fusion oncoproteins in pediatric cancers and to apply novel chemical strategies to accelerate innovative drug discovery and preclinical development of therapeutics for fusion oncoprotein-driven childhood cancers. This NOFO solicits U01 applications for discrete research projects focused on molecular mechanisms by which fusion oncoproteins drive pediatric cancers with the goal of identifying key factors involved in oncogenesis which could serve as critical dependencies or potential targets for therapeutic intervention.