In anticipation of a Cancer Adoptive Cellular Therapy (Can-ACT) Network from the recently published Funding Opportunity Announcements (RFA-CA-22-028, RFA-CA-22-029, RFA-CA-22-030), the National Cancer Institute (NCI) is seeking broad input and feedback on collecting critical clinical and mechanistic data elements for adoptive cellular therapy clinical trials for the treatment of adult and pediatric solid tumors. This request for information (RFI) is part of a planning effort designed to recognize the challenges in cell-based immunotherapy clinical trials data management with respect to data heterogeneity, harmonization, sharing, and reuse, with the purpose of identifying promising opportunities, and developing strategies for successfully collecting, analyzing, integrating and sharing of the Can-ACT clinical trials data and advancing novel cellular immunotherapy clinical testing.
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