Revision Applications for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional)

Application or LOI Due Date
LOI due 1/22/21 for application due date of 2/22/21. Other deadlines: 5/27/21 and 9/29/21 - LOI required and due 30 days prior to app due date.
Brief Description


The purpose of this Funding Opportunity Announcement (FOA) is to encourage revision applications (formerly called "competing revisions") from currently funded NCI U01 research projects. The applicants should propose to expand upon the original research question(s) or otherwise accelerate progress for the parent study by incorporating a new technical approach or instrument developed through support from the NCI Innovative Molecular Analysis Technologies (IMAT) program. Awards from this FOA are meant to incentivize independent validation and to accelerate the adoption of these emerging technologies by appropriate research communities. It is further expected that the research activities in response to this FOA would offer corroborative data to enhance the rigor of new findings and allow further advances that would otherwise have not been possible.

This FOA will utilize the NIH Research Project Cooperative Agreement (U01) mechanism and targets currently funded NCI U01 projects with at least one year left at the estimated time of the award. Applicants cannot request funds beyond the end date of the parent award.

The IMAT Program

Since its inception in 1998, the IMAT Program has focused on stimulating and accelerating the development, integration, and dissemination of highly innovative molecular and cellular analysis and biospecimen science technologies in support of cancer research and clinical care. Together with the NCI's other technology-focused programs, the IMAT program supports the development of tools and methods that enable new discoveries, enhance our understanding of cancer etiology and proliferation, improve detection capabilities, develop diagnostic methods and treatment strategies, conduct population-scale studies, address and reduce disparities in clinical care, and assist in clinical decision- making. Additional information about the IMAT Program and its individual FOAs can be found here.

Non-Responsive Projects

  • Applications seeking to incorporate technology platforms that are commercially available to the research community.
  • Applications proposing to incorporate technologies that were not developed through the support of the NCI IMAT program.

IMPORTANT NOTE: Researchers uncertain as to whether their intended technology development project meets the requirements of this FOA are encouraged to contact the Scientific/Research Contact listed below.

See Section VIII. Other Information for award authorities and regulations.