Notice of Special Interest (NOSI): Research in the Emergency Setting

Organization
NIH
Application or LOI Due Date
09-08-2022
Number
NOT-NS-20-005
Comments
First Available Due Date: 10/5/20.
Brief Description

Purpose

The purpose of this Notice is to announce an interest in research addressing patients with emergency medical conditions, including trauma.

Background

Over 145 million people are seen in emergency departments across the US. Emergency departments are the source of twelve million admissions, or 35% of all hospital admissions and 14% of all outpatient visits. This includes over 27 million children under the age of 15, 23 million adults over the age of 65 and over 42 million visits for injuries and major trauma. When they learn of a patient's new symptoms, primary care providers often use the emergency department to obtain rapid diagnostic tests and a treatment plan.

Emergency Departments are the only component of the country's healthcare system that is accessible at any time of the day or night, and by law they provide treatment regardless of the ability to pay. Rapid assessment and treatment within the first minutes or hours after the onset of illness plays a major role in determining both the trajectory of recovery and future healthcare costs.

Research in the emergency setting offers a unique opportunity to improve not only the treatment of acute life-threatening disorders, but also a spectrum of common disorders that encompass a considerable burden of illness and account for a major component of health care costs.

Research Objectives

This notice invites basic, translational and clinical research and career development programs that effect all areas of emergency medical care, including injury and trauma. Wherever appropriate, investigators are encouraged to utilize existing research networks, such as the NCATS supported CTSAs, NHLBI-NINDS supported SIREN emergency care research network, the NCI CONCERN oncology emergency research network, or the HRSA supported PECARN pedicatric critical care network.

IC Specific Application and Submission Information:

Applicants must select the IC and associated FOA to use for submission of an application in response to this NOSI. The selection must align with the IC requirements listed in order to be considered responsive to that FOA. Non-responsive applications will be withdrawn from consideration for this initiative. In addition, applicants using NIH Parent Announcements (listed below) will be assigned to those ICs on this NOSI that have indicated those FOAs are acceptable and based on usual application-IC assignment practices.

  • PA-20-183 - Research Project Grant (Parent R01 Clinical Trial Required)
  • PA-20-184 - Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
  • PA-20-185 - Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  • PA-20-187 - NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
  • PA-20-188 - NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
  • PA-20-190 - Mentored Research Scientist Development Award (Parent K01 Independent Clinical Trial Not Allowed)
  • PA-20-191 - Mentored Research Scientist Development Award (Parent K01 Independent Basic Experimental Studies with Humans Required)
  • PA-20-194 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
  • PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  • PA-20-196 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)
  • PA-20-201 - Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required)
  • PA-20-202 - Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)
  • PA-20-203 - Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)
  • PA-20-204 - Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required)
  • PA-20-205 - Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)
  • PA-20-206 - Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)
  • PA-20-207 - NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
  • PA-20-260 - PHS 2020 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  • PA-20-261 - PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)
  • PA-20-262 - PHS 2020-2 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
  • PA-20-265 - PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:

  • For funding consideration, applicants must include “NOT-NS-20-005” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative

Applications nonresponsive to terms of this NOSI will be withdrawn from consideration for this initiative.

National Cancer Institute (NCI)

NCI is interested in observational and multilevel intervention studies focused on health-related outcomes in patients with cancer utilizing emergency care services. Interest includes care of patients during active treatment and throughout cancer survivorship.

Research projects may include but are not limited to:

  • Cancer-related utilization of emergency care and the patient, caregiver, clinician, and delivery system factors that drive emergency service use

  • Risk stratification, risk prediction models, and evidence-based strategies to improve health-related outcomes in the cancer population utilizing emergency services

  • Care delivery models and interventions to reduce emergency care use

NCI's FOAs for this NOSI include the following or their subsequent reissued equivalents:

Activity CodeFOAFirst Available Due Date

R01PAR-18-869 - Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)November 6, 2020

R01PAR-18-559 - Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)October 5, 2020

R01PA-20-185 - Research Project Grant (Parent R01 Clinical Trial Not Allowed)October 5, 2020

P01PAR-18-290 - National Cancer Institute Program Project Applications (P01 Clinical Trial Optional)September 25, 2020

R03*PAR-20-052 - NCI Small Grants Program for Cancer Research for Years 2020, 2021, and 2022 (NCI Omnibus R03 Clinical Trial Optional)October 20, 2020

R21PAR-19-309 - Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control (R21 Clinical Trial Optional)October 16, 2020

*See below for NCI-specific contact information for PAR-20-052 only.