Notice of Special Interest (NOSI): Administrative Supplement to a Cancer Moonshot Coordinating Center (U24) to Support the Mechanisms of Cancer Drug Resistance and Sensitivity Network (DRSN)

Organization
NIH
Type
NIH
Application Due Date
06-02-2020
Number
NOT-CA-20-052
Brief Description

This notice informs the current National Cancer Institute (NCI) U24 awardees of NCI’s special interest in administrative supplement applications that seek to support a NCI Moonshot-associated U24 Coordinating Center to help integrate and manage ongoing and future activities of the Cancer Moonshot-funded Mechanisms of Cancer Drug Resistance and Sensitivity Network (DRSN) formed by RFA-CA-17-009 along with DRSN collaborations formed by administrative supplements PAR-18-752 and NOT-CA-19-032. The DRSN Coordinating Center should work to integrate the activities of additional Moonshot investigators funded to research mechanisms of cancer resistance through RFA-CA-19-049-050-051, -052, & -053. This Notice of Special Interest (NOSI) intends to provide funding for one year to an existing Moonshot-associated U24 Coordinating Center to bring DRSN activities up to par with Cancer Moonshot-related policies and guidelines, facilitate DRSN collaborative research by providing analytic and organizational infrastructure and expertise, provide data integration methods and data analysis support, and coordinate DRSN activities with other Cancer Moonshot networks and NCI programs.

Background

The DRSN Coordinating Center oversees DRSN activities, manages and harmonizes data generated across the DRSN, and maximizes the optimal utilization of unique resources. Support includes access to NCI Cancer Therapy Evaluation Program (CTEP), Investigational New Drug (IND) agents within the DRSN, and other Cancer Moonshot Coordinating Centers. The U24 Coordinating Center will promote exchange of scientific findings and potential collaborations between the DRSN investigator teams and across the NCI portfolio.

The DRSN Coordinating Center facilitates data sharing within the DRSN, as well as, between the DRSN and with other Moonshot networks, which will be included in the terms and conditions of the administrative supplement award. The DRSN Coordinating Center and the NCI Center for Biomedical Informatics & Information Technology (CBIIT) team would deposit underlying, primary data for DRSN publications into a repository under the NCI Cancer Research Data Commons.

Specific Research Objectives

The goals of the Coordinating Center to be supported through this administrative supplement are to:
A. Provide a centralized administrative infrastructure to coordinate DRSN activities, which includes organizational, biostatistical, data curation, and collaborative support for basic cancer research studies.
B. Strengthen collaborations within the DRSN and promote DRSN interaction and collaboration with other Cancer Moonshot-funded researchers and networks.
C. Provide multidisciplinary analytic expertise to support DRSN collaborative research.
D. Develop improved data integration methods to enhance DRSN research capacity.
E. Ensure DRSN compliance with NCI Cancer Moonshot policies.

The DRSN Coordinating Center must have expertise and capabilities in biostatistics, information technology, study design, data management, protocol development, and logistical support.