The National Cancer Institute (NCI) is seeking input from the scientific community to identify obstacles and opportunities in the application of systems immunology approaches to reveal underlying principles that regulate immune responses to cancer. This Request for Information (RFI) aims to identify current challenges in the application of systems approaches to advance our understanding of immune system dynamics across the continuum of cancer initiation, progression, invasion, and metastasis, and in the context of prevention, treatment, and intervention. For the purpose of this RFI, cancer systems immunology is defined as the integration of clinical and/or experimental immunology data with computational and mathematical methods to build predictive models of tumor-immune ecosystems that can be tested or validated in a disease-relevant context.
Brief Description