Through this Notice of Special Interest (NOSI), the National Cancer Institute (NCI) invites applications for projects to establish new or to improve existing models that recapitulate cancer development, progression and treatment response in the context of age-related biological changes, and to apply these models in basic and translational cancer research. The “oncoaging” models established through this NOSI are expected to facilitate research into the underlying biology of aging mechanisms which modify cancer susceptibility and progression, and/or alter the trajectory of therapeutic responses. This knowledge is necessary to inform novel cancer therapies for the older population. Responsive projects will be focused on establishing and characterizing cancer models, that consider aging as a risk factor, demonstrating how robustly they recapitulate human biology, assessing their clinical relevance, and validating their utility in mechanistic studies and/or translational research.
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